Non-Opioid Analgesics in Adults After Major Surgery : A Comprehensive Systematic Review
Keywords:
Non-opioid analgesics, postoperative pain, multimodal analgesia, NSAIDs, regional anesthesia, opioid-sparing, major surgery, systematic reviewAbstract
Background: Postoperative pain management remains heavily reliant on opioids, despite risks of addiction, respiratory depression, and ileus. Non-opioid analgesics offer potential alternatives, but their comparative efficacy across major surgeries is unclear.
Methods: This comprehensive systematic review synthesized data from 80 randomized controlled trials, etc evaluating non-opioid analgesics in adults after major surgery. Interventions included NSAIDs, acetaminophen, IV lidocaine, dexamethasone, gabapentinoids, nefopam, regional techniques (epidural, TAP, QLB, paravertebral, EOIP blocks), multimodal protocols, and suzetrigine. Outcomes included pain intensity (VAS/NRS), opioid consumption (morphine equivalents), adverse effects, and recovery metrics.
Results: NSAIDs (IV/IM) consistently reduced pain and opioid use across cesarean, orthopedic, and abdominal surgeries (p<0.001), with etoricoxib reducing morphine by 31-34% (p<0.001) and IV ibuprofen reducing 24h morphine from 39.1mg to 29.8mg (p<0.001). Acetaminophen IV outperformed oral in spine surgery (66% lower morphine equivalents, p=0.001). IV lidocaine significantly accelerated gastrointestinal recovery (flatus reduced by ~6h, bowel movement by ~8h) and reduced opioid consumption by 35% (p<0.001). Dexamethasone reduced pain and opioids (MD -6.66mg morphine equivalents, p<0.001) and enhanced TAP block duration (PONV RR 0.40). Regional techniques: quadratus lumborum block reduced 24h morphine by ~24mg (p<0.01); erector spinae plane block achieved MCID for pain; paravertebral block matched epidural analgesia with fewer adverse events (p=0.02). Multimodal triple therapy (paracetamol+NSAID+adjunct) reduced morphine by 26mg vs. single agents (p<0.001). Opioid-free anesthesia reduced PONV by 40% (RR 0.60) with comparable pain control. Suzetrigine (NaV1.8 inhibitor) showed efficacy equivalent to opioid combinations but without opioid-related AEs (nausea RR 0.72).
Discussion: Non-opioid analgesics provide significant, clinically meaningful reductions in pain and opioid consumption when used as multimodal combinations. Regional techniques are superior for acute nociceptive pain but require systemic NSAIDs for visceral components. IV lidocaine’s primary benefit is gastrointestinal recovery, not late pain relief. Dexamethasone offers dual antiemetic-analgesic benefits. Triple therapy is superior to double or single agents.
Conclusion: Multimodal non-opioid analgesia is highly effective and opioid-sparing after major surgery. Routine adoption of NSAIDs, acetaminophen, dexamethasone, and targeted regional blocks within enhanced recovery protocols is strongly recommended. Cardiac surgery requires further NSAID safety trials. Suzetrigine is a promising novel agent for acute pain.
References
Rawal N, Viscusi E, Peloso P, et al (2013) Evaluation of etoricoxib in patients undergoing total knee replacement surgery in a double-blind, randomized controlled trial. BMC Musculoskeletal Disorders. https://doi.org/10.1186/1471-2474-14-300
Zeng AM, Nami N, Wu CL, Murphy JD (2016) The Analgesic Efficacy of Nonsteroidal Anti-inflammatory Agents (NSAIDs) in Patients Undergoing Cesarean Deliveries: A Meta-Analysis. Regional anesthesia and pain medicine. https://doi.org/10.1097/AAP.0000000000000460
Li X, Zhou P, Li Z, et al (2022) Intravenous Parecoxib for Pain Relief after Orthopedic Surgery: A Systematic Review and Meta-analysis. Pain and Therapy. https://doi.org/10.1007/s40122-022-00400-1
Zhang Z, Xu H, Zhang Y, et al (2017) Nonsteroidal anti-inflammatory drugs for postoperative pain control after lumbar spine surgery: A meta-analysis of randomized controlled trials. Journal of clinical anesthesia. https://doi.org/10.1016/j.jclinane.2017.08.030
Dowe C, Brecevich AT, Grinberg S, et al (2018) Friday, September 28, 2018 9:00 AM–10:00 AM best papers Friday. The spine journal. https://doi.org/10.1016/J.SPINEE.2018.06.415
Paschal GK, Avrumova F, Paschal PK, et al (2022) P142. Single center, randomized controlled trial of intravenous vs oral acetaminophen administration in perioperative care of 1 and 2 level LLIFs with instrumented posterior lumbar fusion: a comparative effectiveness study. The spine journal. https://doi.org/10.1016/j.spinee.2022.06.399
Altenau B, Crisp C, Devaiah G, Lambers D (2017) Randomized controlled trial of intravenous acetaminophen for postcesarean delivery pain control. American Journal of Obstetrics and Gynecology. https://doi.org/10.1097/01.aoa.0000527062.81529.c0
Heybati K, Zhou F, Lynn M, et al (2023) Comparative Efficacy of Adjuvant Nonopioid Analgesia in Adult Cardiac Surgical Patients: A Network Meta-Analysis. Journal of Cardiothoracic and Vascular Anesthesia. https://doi.org/10.1053/j.jvca.2023.03.018
H PKK, Navalyal SR, Naganagoudar H, Hoogar P (2025) Efficacy of Intravenous Infusion of Lignocaine on Bowel Function Recovery and Postoperative Pain After Major Abdominal Surgery. Journal of Neonatal Surgery. https://doi.org/10.63682/jns.v14i32s.8401
Ng K, Lim WE, Teoh W, Abidin MFZ (2026) Analgesic Effects of Intravenous Lidocaine in Laparoscopic Surgery. The Clinical Journal of Pain. https://doi.org/10.1097/ajp.0000000000001386
Kranke P, Jokinen J, Pace N, et al (2015) Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD009642.pub2
Paterson H (2019) Continuous intravenous lidocaine infusion for postoperative pain and recovery in adults. Techniques in Coloproctology. https://doi.org/10.1007/s10151-018-1890-2
Mitchell C, Mitchell C, Cheuk S, et al (2021) What is the impact of dexamethasone on postoperative pain in adults undergoing general anaesthesia for elective abdominal surgery: a systematic review and meta-analysis. Perioperative Medicine. https://doi.org/10.1186/s13741-022-00243-6
Gasbjerg KS, Hägi‐Pedersen D, Lunn T, et al (2022) Effect of dexamethasone as an analgesic adjuvant to multimodal pain treatment after total knee arthroplasty: randomised clinical trial. British medical journal. https://doi.org/10.1136/bmj-2021-067325
Zhang D, Zhou C, Wei D, et al (2019) Dexamethasone added to local anesthetics in ultrasound-guided transversus abdominis plain (TAP) block for analgesia after abdominal surgery: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE. https://doi.org/10.1371/journal.pone.0209646
Qin C, Liu Y, Xiong J, et al (2020) The analgesic efficacy compared ultrasound-guided continuous transverse abdominis plane block with epidural analgesia following abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiology. https://doi.org/10.1186/s12871-020-00969-0
Bae S, Alboog A, Esquivel KS, et al (2021) Efficacy of perioperative pharmacological and regional pain interventions in adult spine surgery: a network meta-analysis and systematic review of randomised controlled trials. British Journal of Anaesthesia. https://doi.org/10.1016/j.bja.2021.08.034
Homma T, Doki Y, Yamamoto Y, et al (2019) Efficacy of 50 mg pregabalin for prevention of postoperative neuropathic pain after video-assisted thoracoscopic surgery and thoracotomy: a 3-month prospective randomized controlled trial. Journal of Thoracic Disease. https://doi.org/10.21037/JTD.2019.02.77
Bersot C, Silva PVE da, Barros MRRM, et al (2026) Opioid‐Free Versus Opioid‐Based Anesthesia in Laparoscopic Surgery: Systematic Review and Meta‐Analysis Across Multiple Perioperative Outcomes. Anesthesiology Research and Practice. https://doi.org/10.1155/anrp/2082149
Saeed O, Saeed A, Nounou M, et al (2026) Opioid-based vs. opioid-free analgesia in hip arthroplasty: a systematic review and meta-analysis. Anaesthesia Critical Care & Pain Medicine. https://doi.org/10.1016/j.accpm.2026.101763
Espelund M, Fomsgaard J, Haraszuk J, et al (2013) Analgesic efficacy of ultrasound-guided adductor canal blockade after arthroscopic anterior cruciate ligament reconstruction: A randomised controlled trial. European Journal of Anaesthesiology. https://doi.org/10.1097/EJA.0b013e328360bdb9
Sparber L, Lau CSM, Vialet TS, Chamberlain R (2017) Preoperative intravenous ibuprofen does not influence postoperative narcotic use in patients undergoing elective hernia repair: a randomized, double-blind, placebo controlled prospective trial. Journal of Pain Research. https://doi.org/10.2147/JPR.S132836
Cuvillon P, Zoric L, Demattei C, et al (2017) Opioid-sparing effect of nefopam in combination with paracetamol after major abdominal surgery: a randomized double-blind study. Minerva Anestesiologica. https://doi.org/10.23736/S0375-9393.17.11508-7
Bertoch T, D’Aunno D, McCoun J, et al (2025) Suzetrigine, a Nonopioid NaV1.8 Inhibitor for Treatment of Moderate-to-severe Acute Pain: Two Phase 3 Randomized Clinical Trials. Anesthesiology. https://doi.org/10.1097/ALN.0000000000005460
Burhan M, Ashraf S, Raza SHA, et al (2025) Efficacy and Safety of Suzetrigine for Acute Postoperative Pain: A GRADE Assessed Systematic Review and Meta-Analysis. Journal of Pain & Palliative Care Pharmacotherapy. https://doi.org/10.1080/15360288.2025.2587188
Zhang H, Huang J, Xu H, et al (2021) Intravenous Ibuprofen 400 Versus 800 mg Every 6 Hours in Abdominal and Orthopedic Surgery: A Multicenter, Randomized Controlled Trial. https://doi.org/10.21203/rs.3.rs-799074/v1
Huette P, Moussa M, Diouf M, et al (2024) Effect of non-steroidal anti-inflammatory drugs on the management of postoperative pain after cardiac surgery: a multicenter, randomized, controlled, double-blind trial (KETOPAIN Study). Trials. https://doi.org/10.1186/s13063-024-08326-z
Bilir S, Yurtlu BS, Hancı V, et al (2016) Effects of peroperative intravenous paracetamol and lornoxicam for lumbar disc surgery on postoperative pain and opioid consumption: A randomized, prospective, placebo-controlled study. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology. https://doi.org/10.5505/agri.2015.45220
Hutchins J, Grandelis A, Kaizer A, Jensen E (2018) Thoracic paravertebral block versus thoracic epidural analgesia for post-operative pain control in open pancreatic surgery: A randomized controlled trial. Journal of clinical anesthesia. https://doi.org/10.1016/j.jclinane.2018.04.013
Yadav G, Choupoo S, Das SK, et al (2014) Evaluating the Role of Flupirtine for Postcraniotomy Pain and Compare it With Diclofenac Sodium: A Prospective, Randomized, Double Blind, Placebo-controlled Study. Journal of Neurosurgical Anesthesiology. https://doi.org/10.1097/ANA.0b013e31829a04ad
Barazanchi A, MacFater WS, Rahiri J-L, et al (2018) Evidence‐based management of pain after laparoscopic cholecystectomy: a PROSPECT review update. British Journal of Anaesthesia. https://doi.org/10.1016/j.bja.2018.06.023
Mousad AD, Nithagon P, Grant AR, et al (2024) Non-Opioid Analgesia Protocols after Total Hip Arthroplasty and Total Knee Arthroplasty: An Updated Scoping Review and Meta-Analysis. Journal of Arthroplasty. https://doi.org/10.1016/j.arth.2024.11.013
Thybo K, Hägi‐Pedersen D, Dahl J, et al (2019) Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial. Journal of the American Medical Association (JAMA). https://doi.org/10.1001/jama.2018.22039
Fiore G, Porto E, Pluderi M, et al (2023) Prevention of Post-Operative Pain after Elective Brain Surgery: A Meta-Analysis of Randomized Controlled Trials. Medicina. https://doi.org/10.3390/medicina59050831
Guo X, Wang Z, Gao L, et al (2021) Nonsteroidal antiinflammatory drugs versus tramadol in pain management following transsphenoidal surgery for pituitary adenomas: a randomized, double-blind, noninferiority trial. Journal of Neurosurgery. https://doi.org/10.3171/2021.8.JNS211637
Barry G, Sehmbi H, Retter S, et al (2023) Comparative efficacy and safety of non-neuraxial analgesic techniques for midline laparotomy: a systematic review and frequentist network meta-analysis of randomised controlled trials. British Journal of Anaesthesia. https://doi.org/10.1016/j.bja.2023.08.024
Baumann AN, Fiorentino A, Sidloski K, et al (2024) The Impact of Ketorolac Utilization on Outcomes for Lumbar Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. World Neurosurgery. https://doi.org/10.1016/j.wneu.2024.01.042
Guay J, Kopp S (2019) Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD006715.pub3
Lee H-J, Choi S, Yoon S, et al (2024) Effect of an intravenous acetaminophen/ibuprofen fixed-dose combination on postoperative opioid consumption and pain after video-assisted thoracic surgery: a double-blind randomized controlled trial. Surgical Endoscopy. https://doi.org/10.1007/s00464-024-10821-y
He H, Li C, Wen Z, et al (2025) Which Analgesic Should We Use to Relieve Pain After Knee or Hip Arthroplasty? A Systematic Review and Network Meta-analysis of RCTs. Clinical Orthopaedics and Related Research. https://doi.org/10.1097/CORR.0000000000003749
B DrB kumar (2024) OPTIMIZING POSTOPERATIVE ANALGESIA: A RANDOMIZED COMPARISON OF INTRAVENOUS IBUPROFEN AND PARACETAMOL IN ABDOMINAL STOMA CLOSURE. Journal of Population Therapeutics and Clinical Pharmacology. https://doi.org/10.53555/s935a224
Amin SM, Hasanin A, Soliman S, et al (2025) Intravenous Ibuprofen Versus Ketorolac for Perioperative Pain Control in Patients with Morbid Obesity Undergoing Bariatric Surgery: A Randomized Controlled Trial. Obesity Surgery. https://doi.org/10.1007/s11695-025-07752-5
Shepherd D, Jahnke H, White W, Little A (2017) Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery. Journal of Neurosurgery. https://doi.org/10.3171/2016.10.JNS161355
Swenson J, Conrad KM, Pace N, et al (2022) Scheduled, Simultaneous Dosing of Pregabalin, Celecoxib, and Acetaminophen Markedly Reduces or Eliminates Opioid Use After ACL Reconstruction Using Allograft or Hamstring Tendon Autograft: A Randomized Clinical Trial. Orthopaedic Journal of Sports Medicine. https://doi.org/10.1177/23259671221140837
Pinsornsak P, Sukkankosol S, Boontanapibul K (2022) Does Nefopam Provide Analgesic Effect and Reduce Morphine Consumption after Primary Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial. Journal of Arthroplasty. https://doi.org/10.1016/j.arth.2022.01.079
Negm EM, Younus M, Morsy AA, et al (2025) Opioid-sparing multimodal analgesia for post-craniotomy pain: a randomized, double-blind, placebo-controlled trial. BMC Anesthesiology. https://doi.org/10.1186/s12871-025-03306-5
Singla N, Bindewald M, Singla S, et al (2018) Efficacy and Safety of Intravenous Meloxicam in Subjects with Moderate-to-severe Pain Following Abdominoplasty. Plastic and Reconstructive Surgery, Global Open. https://doi.org/10.1097/GOX.0000000000001846
Rastogi B, Singh V, Gupta K, et al (2016) Postoperative analgesia after laparoscopic cholecystectomy by preemptive use of intravenous paracetamol or ketorolac: A comparative study. Indian Journal of Pain. https://doi.org/10.4103/0970-5333.173460
Ki H, Shim J-G, Choi H-K, et al (2023) Nefopam as a multimodal analgesia in thoracoscopic surgery: a randomized controlled trial. Journal of Thoracic Disease. https://doi.org/10.21037/jtd-24-30
Saran A, Hoda W, Pandey K, et al (2026) External oblique intercostal plane block for postoperative analgesia: A systematic review and meta-analysis of randomised controlled trials. Indian Journal of Anaesthesia. https://doi.org/10.4103/ija.ija_1074_25
Berkowitz R, Steinfeld R, Sah A, et al (2021) Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial. Pain medicine (Malden, Mass). https://doi.org/10.1093/pm/pnab016
Saraev AV, Kornilov NN (2023) Efficacy of Novel Oral Non-Steroid Anti-Inflammatory Drugs for Pain Management After Total Knee Arthroplasty. Traumatology and Orthopedics of Russia. https://doi.org/10.17816/2311-2905-8006
Mazzinari G, Rovira L, Casasempere A, et al (2018) Interfascial block at the serratus muscle plane versus conventional analgesia in breast surgery: a randomized controlled trial. Regional anesthesia and pain medicine. https://doi.org/10.1136/rapm-2018-000004
Sharpe K, Berkowitz R, Tyndall W, et al (2020) Safety, Tolerability, and Effect on Opioid Use of Meloxicam IV Following Orthopedic Surgery. Journal of Pain Research. https://doi.org/10.2147/JPR.S216219
Nikooseresht M, Seifrabiei M, Davoodi M, et al (2016) Diclofenac Suppository vs. IV Acetaminophen Combined With IV PCA for Postoperative Pain Management in Patients Undergoing Laminectomy: A Randomized, Double-Blinded Clinical Trial. Anesthesiology and Pain Medicine. https://doi.org/10.5812/aapm.36812
Hostage JC, Kolettis D, Sverdlov DY, et al (2023) Increased Scheduled Intravenous Ketorolac After Cesarean Delivery and Its Effect on Opioid Use. Obstetrics and Gynecology. https://doi.org/10.1097/AOG.0000000000005120
Bhatia N, Jain K, Kumari K, et al (2023) Opioid-sparing post-cesarean analgesia using intravenous diclofenac-acetaminophen combination: A prospective, randomized clinical trial. Journal of Obstetric Anaesthesia and Critical Care. https://doi.org/10.4103/JOACC.JOACC_49_22
Kinoshita J, Hayashi S, Tsuji T, et al (2026) Scheduled intravenous acetaminophen versus thoracic epidural analgesia for postoperative pain control after minimally invasive gastrectomy: multicentre randomized non-inferiority trial. BJS Open. https://doi.org/10.1093/bjsopen/zrag031
Essex M, Choi H-Y, Brown PB, Cheung R (2018) A randomized study of the efficacy and safety of parecoxib for the treatment of pain following total knee arthroplasty in Korean patients. Journal of Pain Research. https://doi.org/10.2147/JPR.S147481
Yuan W, Wang Z, Pu J, Huang X-C (2026) Analgesic efficacy of multiple regional nerve block techniques in laparoscopic hepatectomy: a systematic review and meta-analysis. BMC Anesthesiology. https://doi.org/10.1186/s12871-026-03630-4
Amin SM, Hasanin A, Attia OA, et al (2024) Intravenous ibuprofen versus ketorolac for perioperative pain control in open abdominal hysterectomy: a randomized controlled trial. BMC Anesthesiology. https://doi.org/10.1186/s12871-024-02571-0
Ramírez-González M, Torres-Lugo NJ, Deliz-Jimenez D, et al (2023) Efficacy of an Opioid-Sparing Perioperative Multimodal Analgesia Protocol on Posterior Lumbar Fusion in a Hispanic Population: A Randomized Controlled Trial. Journal of the American Academy of Orthopaedic Surgeons. https://doi.org/10.5435/JAAOS-D-22-00878
Ustun YB, Turunç E, Ozbalcı GS, et al (2022) Comparison of Ketamine, Dexmedetomidine and Lidocaine in Multimodal Analgesia Management Following Sleeve Gastrectomy Surgery: A Randomized Double-Blind Trial. Journal of Perianesthesia Nursing. https://doi.org/10.1016/j.jopan.2021.12.012
Hostage JC, Kolettis D, Sverdlov DY, et al (2023) Opioid use after cesarean with and without scheduled ketorolac administration: a randomized control trial. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2022.11.013
Koo C, Ahn S, Na H, et al (2021) Efficacy of quadratus lumborum block for analgesia in adult participants undergoing hip surgery: A meta-analysis of randomized controlled trials. Journal of clinical anesthesia. https://doi.org/10.1016/j.jclinane.2021.110560
Wang VC, Preston M, Kibel A, et al (2018) A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate Intravenous Acetaminophen Versus Placebo in Patients Undergoing Robotic-Assisted Laparoscopic Prostatectomy. Journal of Pain & Palliative Care Pharmacotherapy. https://doi.org/10.1080/15360288.2018.1513436
Admiraal M, Smulders PSH, Rutten M, et al (2024) The effectiveness of ambulatory continuous popliteal sciatic nerve blockade on patient-reported overall benefit of analgesia in patients undergoing foot or ankle surgery (CAREFREE trial); a randomized, open label, non-inferiority trial. Journal of clinical anesthesia. https://doi.org/10.1016/j.jclinane.2024.111451
Tubsrinuan K, Sa-ngasoongsong P, Jarungvittayakon C, et al (2025) Efficacy of NSAID Transdermal Patch for Postoperative Management in Total Knee Arthroplasty. Journal of Clinical Medicine. https://doi.org/10.3390/jcm14228098
Gond P, Agrawal R, Chaudhary J, Kumar S (2025) A Prospective Randomized Comparative Study: Efficacy of Intravenous Ibuprofen Infusion Used as Pre-Emptive Analgesia in Patients Undergoing Elective Laparoscopic Cholecystectomy. International Journal of Pharmaceutical Quality Assurance. https://doi.org/10.25258/ijpqa.16.9.19
Iyer S, Zgonis EM, Steinhaus ME, et al (2019) 2017 Research Grant: Intravenous ketorolac substantially reduces opioid use following lumbar spinal fusion: early results of a randomized, double-blinded, placebo controlled trial. The spine journal. https://doi.org/10.1016/J.SPINEE.2019.05.290
Baheti S, Singh V (2025) Efficacy of Diclofenac and Ketoprofen Transdermal Patches for Postoperative Analgesia and their Effect on Renal Functions in Patients Undergoing Percutaneous Nephrolithotomy: A Randomised Clinical Study. Journal of Clinical and Diagnostic Research. https://doi.org/10.7860/jcdr/2025/79656.21317
Rashtchi V, Gholami H, Zamanpour N, Yari HF (2026) A Comparative Analysis of the Effects of Oral Gabapentin and Intravenous Dexamethasone on Postoperative Pain Following Hysterectomy: A Randomized Clinical Trial. Biomedical Research and Therapy. https://doi.org/10.15419/p30hb731
Al-Nasrawi AN, Al-Ibrahim MW, Aljabran S (2024) Evaluating the Efficacy of Methocarbamol and Nefopam in Orthopedic Surgical Pain. Cureus. https://doi.org/10.7759/cureus.59533
Ramzan MM, Farrukh K, Ikram A (2025) Comparison of Pain with Systemic NSAIDs vs Regional Block (Fascia Iliaca) in Cases with Hip Fracture. Biological and Clinical Sciences Research Journal. https://doi.org/10.54112/bcsrj.v6i6.1968
Turunç E, Dost B, Kaya C, et al (2025) Efficacy of anterior subcostal quadratus lumborum block for postoperative analgesia in laparoscopic colorectal surgery: a randomized controlled trial. Regional anesthesia and pain medicine. https://doi.org/10.1136/rapm-2025-107136
Wang W, Yuan C, Wang F, et al (2026) A Bayesian network meta-analysis of peripheral nerve blocks for postoperative analgesia in adults following hip fracture surgery. BMC Surgery. https://doi.org/10.1186/s12893-026-03609-5
Abdelbadie M (2022) Analgesic efficacy of the erector spinae plane block using bupivacaine vs. bupivacaine/magnesium sulphate in patients undergoing lumbar spine surgery: a randomized, double-blinded comparative study. Anaesthesia, Pain & Intensive Care. https://doi.org/10.35975/apic.v26i4.1945
Moon PK, Wei EX, Hamid M, et al (2023) Nonopioid Versus Opioid Analgesics After Thyroid and Parathyroid Surgery: A Systematic Review. Otolaryngology Head & Neck Surgery. https://doi.org/10.1002/ohn.503
Weibel S, Jelting Y, Pace N, et al (2018) Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD009642.pub3
Biput SJ, Slouha E, Gregory JA, et al (2024) Pain Management During Adult Laparoscopic Appendectomy: A Systematic Review. Cureus. https://doi.org/10.7759/cureus.52037
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