Is a sedentary lifestyle associated with a decrease in semen quality in adult men aged 18-50 years? A Systematic Review
Keywords:
sedentary lifestyle, sedentary behavior, semen quality, sperm parameters, male fertility, physical activityAbstract
Introduction: Global declines in semen quality over recent decades have raised concerns about the impact of modern lifestyles on male fertility. Sedentary behavior, increasingly prevalent in occupational and leisure settings, has been hypothesized as a potential contributing factor. This systematic review aims to evaluate whether a sedentary lifestyle is associated with decreased semen quality in healthy adult men aged 18-50 years.
Methods: A systematic review was conducted following predefined screening criteria. Sixteen studies were included randomized controlled trial, etc. Studies were required to assess sedentary behavior (directly or indirectly), evaluate semen quality parameters (concentration, motility, morphology, volume, DNA fragmentation), and include healthy adult men aged 18-50 years. Data were extracted on study characteristics, sedentary behavior definitions, semen parameters, association findings, confounding factors, and limitations.
Results: Direct evidence from two studies specifically measuring sedentary behavior showed inconsistent findings. Sterpi et al. (2024) reported mixed results across 13,509 men: three studies found declines in sperm concentration with high sedentary time, but most studies showed no significant associations with concentration, motility, or morphology. Eisenberg et al. (2015) found no association between occupational prolonged sitting and any semen parameter after adjustment for confounders. Indirect evidence from physical activity studies suggested that moderate physical activity benefits semen quality, while intense exercise may be detrimental (Montano et al., 2021; Nesello et al., 2020; Zańko et al., 2022). Obesity, strongly correlated with sedentary behavior, consistently predicted impaired semen quality (Magoutas et al., 2025; Venishetty et al., 2024; Бобков et al., 2020).
Discussion: The available evidence does not demonstrate a robust independent association between sedentary behavior and decreased semen quality. Methodological limitations include heterogeneous definitions of sedentary behavior, reliance on self-report measures, inadequate adjustment for confounders (particularly BMI/obesity), and selection bias across study populations. The pathway linking sedentary behavior to semen quality appears mediated primarily through metabolic consequences (obesity, hormonal imbalances) rather than direct effects.
Conclusion: Current evidence is insufficient to establish a causal relationship between sedentary lifestyle and decreased semen quality in healthy adult men aged 18-50 years. High-quality prospective studies using objective sedentary behavior measures (accelerometry) with adequate adjustment for adiposity and confounders are needed. Future research should distinguish between sedentary behavior's independent effects and those mediated through obesity.
References
Vittoria Sterpi, E. Ricci, F. Chiaffarino, et al (2024) The sitting men: A systematic review of spare and working time exposure to sedentariness in relation to semen parameters. Andrology. https://doi.org/10.1111/andr.13816
M. Eisenberg, Zhen Chen, A. Ye, G. B. Buck Louis (2015) Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2015.02.010
L. Montano, E. Ceretti, F. Donato, et al (2021) Effects of a Lifestyle Change Intervention on Semen Quality in Healthy Young Men Living in Highly Polluted Areas in Italy: The FASt Randomized Controlled Trial. European Urology Focus. https://doi.org/10.1016/j.euf.2021.01.017
A. Zańko, Katarzyna Siewko, A. Krętowski, R. Milewski (2022) Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors of Male Infertility. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph20010732
L. Nesello, F. Pasqualotto (2020) Efeito da atividade física sobre a qualidade seminal. https://doi.org/10.36453/2318-5104.2020.V18.N1.P41
Kristina Magoutas, S. Leathersich, Roger Hart, et al (2025) Lower Semen Quality Among Men in the Modern Era—Is There a Role for Diet and the Microbiome? Microorganisms. https://doi.org/10.3390/microorganisms13010147
Д. Н. Бобков, Р. В. Роживанов, Л. В. Савельева (2020) Показатели качества эякулята, ассоциированные со снижением массы тела у молодых бесплодных мужчин с патозооспермией, постпубертатным висцеральным ожирением и неотягощенным андрологическим анамнезом. https://doi.org/10.14341/OMET12679-9836
C. Zani, D. Zani, F. Donato, et al (2019) Lifestyle, environmental exposures and male fertility in healthy young men in North Italy. European Journal of Public Health. https://doi.org/10.1093/eurpub/ckz186.459
R. Hayden, R. Flannigan, P. Schlegel (2018) The Role of Lifestyle in Male Infertility: Diet, Physical Activity, and Body Habitus. Current Urology Reports. https://doi.org/10.1007/s11934-018-0805-0
R. Rahban, S. Nef (2020) Regional difference in semen quality of young men: a review on the implication of environmental and lifestyle factors during fetal life and adulthood. Basic and Clinical Andrology. https://doi.org/10.1186/s12610-020-00114-4
J. Silva, D. Cruz, Mariana Gomes, et al (2017) Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men’s seminal quality. Scientific Reports. https://doi.org/10.1038/srep45457
Mohammad Masum Hasan, Taslima Begum, M. Amin, Sharif Muhammad Mahmudul Hasan Majumder (2024) Falling Sperm Counts in the Past 40 Years among Western Men: A Review Article. Journal of Comilla Medical College Teachers' Association. https://doi.org/10.3329/jcomcta.v28i2.78021
Xuefeng Luo, Chongyang Yin, Yuqing Shi, et al (2023) Global trends in semen quality of young men: a systematic review and regression analysis. Journal of Assisted Reproduction and Genetics. https://doi.org/10.1007/s10815-023-02859-z
S. Venishetty, M. Scott, A. Rodriguez, S. Lundy (2024) (242) THE IMPACT OF ENVIRONMENTAL FACTORS AND CHRONIC MEDICAL CONDITIONS ON SEMEN PARAMETERS: A TEN-YEAR LONGITUDINAL ANALYSIS. Journal of Sexual Medicine. https://doi.org/10.1093/jsxmed/qdae167.236
J. Jurewicz, M. Radwan, Dorota Merecz-Kot, et al (2014) Occupational, life stress and family functioning: does it affect semen quality? Annals of Human Biology. https://doi.org/10.3109/03014460.2013.849755
M. Ulstein (1996) Semen quality—has it changed during the last decades? Acta Obstetricia et Gynecologica Scandinavica. https://doi.org/10.3109/00016349609047086
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Copyright (c) 2026 Rizky Febriansyah, Bangar Parlinggoman Tua, Mutia Juliana, Aditya Rifandi Zaenudin (Author)
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