Efficacy and Safety of Chloroquine in Patient with COVID-19
A Comprehensive Systematic Review
Keywords:
Chloroquine, covid-19, efficacy, SARS-CoVAbstract
Background: Chloroquine is a potent inhibitor of the SARS Coronavirus (SARS-CoV) and SARS-CoV-2 in in vitro studies, and has been suggested to exhibit antiviral activity against Zika virus, poliovirus, HIV, and influenza viruses A & B. Methods: This systematic review focused on full-text English literature published between 2014 and 2024 using the PRISMA 2020 guidelines. Editorials and review pieces published in the same journal as the submission without a DOI were not accepted. Result: Five publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: No significant beneficial effect of using chloroquine on the outcome of patients with COVID-19.
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