The Analysis Study of Efficacy, Effectiveness, and Clinical Risk of Tramadol as Treatment of Premature Ejaculation : A Comprehensive Systematic Review
Keywords:
Premature ejaculation, tramadol, effectiveness, efficacy, safetyAbstract
Background: Premature ejaculation is a common sexual dysfunction affecting 20%-30% of men. Understanding the effectiveness and potential dangers of tramadol in treating premature ejaculation can help develop efficient treatment protocols. Methods: In accordance with the PRISMA 2020 principles, this systematic review focused specifically on comprehensive English literature published from 2013 to 2024. Result: The study examined over 2000 papers from respectable sources such as Science Direct, SagePub, and PubMed. Following the decision to subject eight publications to further scrutiny, a comprehensive examination of the complete body of literature was conducted. Conclusion: Tramadol, an analgesic derived from opioids, effectively suppresses premature ejaculation (PE) and enhances sexual satisfaction during sexual intercourse. Nevertheless, the efficacy and safety of its use in treating PE are still a subject of discussion due to a lack of solid empirical evidence. Additional investigation is required to ascertain the effectiveness of the medication and its possible adverse effects.
References
Raveendran AV, Agarwal A. Premature ejaculation - current concepts in the management: A narrative review. Int J Reprod Biomed. 2021 Jan 25;19(1):5-22. doi: 10.18502/ijrm.v19i1.8176. PMID: 33553999; PMCID: PMC7851481.
Althof SE, Abdo CH, Dean J, Hackett G, McCabe M, McMahon CG, Rosen RC, Sadovsky R, Waldinger M, Becher E, Broderick GA, Buvat J, Goldstein I, El-Meliegy AI, Giuliano F, Hellstrom WJ, Incrocci L, Jannini EA, Park K, Parish S, Porst H, Rowland D, Segraves R, Sharlip I, Simonelli C, Tan HM; International Society for Sexual Medicine. International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med. 2010 Sep;7(9):2947-69. doi: 10.1111/j.1743-6109.2010.01975.x. PMID: 21050394.
Serefoglu EC, McMahon CG, Waldinger MD, Althof SE, Shindel A, Adaikan G, Becher EF, Dean J, Giuliano F, Hellstrom WJ, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, Torres LO. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation. J Sex Med. 2014 Jun;11(6):1423-41. doi: 10.1111/jsm.12524. Epub 2014 May 22. PMID: 24848805.
Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJ, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, Torres LO. An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Sex Med. 2014 Jun;2(2):60-90. doi: 10.1002/sm2.28. PMID: 25356302; PMCID: PMC4184677.
Lee HY, Pyun JH, Shim SR, Kim JH. Efficacy of Various Treatment in Premature Ejaculation: Systematic Review and Network Meta-Analysis. World J Mens Health. 2024 Apr;42(2):338-346. doi: 10.5534/wjmh.230030. Epub 2023 Aug 9. PMID: 37635338; PMCID: PMC10949017.
McMahon CG. Emerging and investigational drugs for premature ejaculation. Transl Androl Urol. 2016 Aug;5(4):487-501. doi: 10.21037/tau.2016.04.02. PMID: 27652222; PMCID: PMC5001989.
Sharma AP, Sharma G, Tyagi S, Devana SK, Mavuduru RS, Bora GS, Singh SK. Safety and efficacy of "on-demand" tramadol in patients with premature ejaculation: an updated meta-analysis. Int Braz J Urol. 2021 Sep-Oct;47(5):921-934. doi: 10.1590/S1677-5538.IBJU.2020.0561. PMID: 33566469; PMCID: PMC8321462.
Yang L, Qian S, Liu H, Liu L, Pu C, Han P, Wei Q. Role of tramadol in premature ejaculation: a systematic review and meta-analysis. Urol Int. 2013;91(2):197-205. doi: 10.1159/000348826. Epub 2013 Jun 6. PMID: 23751284.
Castiglione F, Albersen M, Hedlund P, Gratzke C, Salonia A, Giuliano F. Current Pharmacological Management of Premature Ejaculation: A Systematic Review and Meta-analysis. Eur Urol. 2016 May;69(5):904-16. doi: 10.1016/j.eururo.2015.12.028. Epub 2015 Dec 31. PMID: 26749092.
Gur S, Sikka SC. The characterization, current medications, and promising therapeutics targets for premature ejaculation. Andrology. 2015 May;3(3):424-42. doi: 10.1111/andr.12032. Epub 2015 May 7. PMID: 25951512.
Martyn-St James M, Cooper K, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, Frodsham L, Hood C. Tramadol for premature ejaculation: a systematic review and meta-analysis. BMC Urol. 2015 Jan 30;15:6. doi: 10.1186/1471-2490-15-6. PMID: 25636495; PMCID: PMC4417346.
Jian Z, Wei X, Ye D, Li H, Wang K. Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis. Int Urol Nephrol. 2018 Nov;50(11):1939-1948. doi: 10.1007/s11255-018-1984-9. Epub 2018 Sep 17. PMID: 30225547.
Tan H, Zhou Z, Cui Y, Feng F, Zhang Y. A systematic review and meta-analysis of randomized controlled trials of "on-demand" use of tramadol vs "on-demand" use of paroxetine in the management of patients with premature ejaculation. Int J Clin Pract. 2021 Nov;75(11):e14825. doi: 10.1111/ijcp.14825. Epub 2021 Sep 16. PMID: 34492139.
Mulhall JP. Current and future pharmacotherapeutic strategies in treatment of premature ejaculation. Urology. 2006 Jan;67(1):9-16. doi: 10.1016/j.urology.2005.07.051. PMID: 16413323.
McMahon CG, Porst H. Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation. J Sex Med. 2011 Oct;8(10):2707-25. doi: 10.1111/j.1743-6109.2011.02386.x. Epub 2011 Jul 19. PMID: 21771283.
Kaynar M, Kilic O & Yurdakul T. (2012) On-demand tramadol hydrochloride use in premature ejaculation treatment. Urology 79, 145–149. doi: 10.1016/j.urology.2011.09.031.
Eassa BI, El-Shazly MA. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Asian J Androl. 2013 Jan;15(1):138-42. doi: 10.1038/aja.2012.96. Epub 2012 Oct 29. PMID: 23103596; PMCID: PMC3739134.
Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, Vardi Y, Wespes E; European Association of Urology. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol. 2010 May;57(5):804-14. doi: 10.1016/j.eururo.2010.02.020. Epub 2010 Feb 20. PMID: 20189712.
Epstein DH, Preston KL, Jasinski DR. Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol. Biol Psychol. 2006 Jul;73(1):90-9. doi: 10.1016/j.biopsycho.2006.01.010. Epub 2006 Feb 23. PMID: 16497429; PMCID: PMC2943845.
Bar-Or D, Salottolo KM, Orlando A, Winkler JV; Tramadol ODT Study Group. A randomized double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Eur Urol. 2012 Apr;61(4):736-43. doi: 10.1016/j.eururo.2011.08.039. Epub 2011 Aug 30. PMID: 21889833.
Safarinejad MR, Hosseini SY. Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol. 2006 Feb;26(1):27-31. doi: 10.1097/01.jcp.0000195110.79027.3f. Retraction in: J Clin Psychopharmacol. 2022 Mar-Apr 01;42(2):230. doi: 10.1097/JCP.0000000000001538. PMID: 16415702.
Montague DK, Jarow J, Broderick GA, Dmochowski RR, Heaton JP, Lue TF, Nehra A, Sharlip ID; AUA Erectile Dysfunction Guideline Update Panel. AUA guideline on the pharmacologic management of premature ejaculation. J Urol. 2004 Jul;172(1):290-4. doi: 10.1097/01.ju.0000132159.61156.ea. PMID: 15201797.
Giuliano FA. Tramadol for the treatment of premature ejaculation. Eur Urol. 2012 Apr;61(4):744-5. doi: 10.1016/j.eururo.2011.09.013. Epub 2011 Sep 28. PMID: 21978420.
Puppo V, Puppo G. Comprehensive review of the anatomy and physiology of male ejaculation: Premature ejaculation is not a disease. Clin Anat. 2016 Jan;29(1):111-9. doi: 10.1002/ca.22655. Epub 2015 Oct 30. PMID: 26457680.
Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleves MA. Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med. 2008 Jan;5(1):188-93. doi: 10.1111/j.1743-6109.2006.00424.x. Epub 2007 Mar 14. PMID: 17362279.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Dhimas Mohammad Fajar Nugraha, Tsalitsa Laili Akmalia (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
